CUED Publications database

Biexcitability and bursting mechanisms in neural and genetic circuits

Gifani, P and Goncalves, J (2014) Biexcitability and bursting mechanisms in neural and genetic circuits. In: UNSPECIFIED pp. 4394-4399..

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This paper compares mechanisms for generating repetitive spikes (bursts) in neural and transcriptional circuits. Neurons generate bursts followed by refractory periods controlled by ion channels in the membrane. In contrast, in gene transcription the bursts occur during a short time period followed by silent periods regulated by sis-regulatory elements. The role of excitability in producing different patterns of bursts is discussed by comparing the topology of a neural model with natural and synthetic transcriptional genetic circuits. In particular, a special bi-excitable architecture which embeds two excitable states are compared in these systems.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:45
Last Modified: 27 Apr 2021 06:28
DOI: 10.3182/20140824-6-za-1003.02630