CUED Publications database

Sensitivity analysis of circadian entrainment in the space of phase response curves

Sacré, P and Sepulchre, R (2014) Sensitivity analysis of circadian entrainment in the space of phase response curves. In: A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems. UNSPECIFIED, pp. 59-81.

Full text not available from this repository.

Abstract

© 2014 Springer Science+Business Media Dordrecht. All rights reserved. Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given parameter in a given system characteristic. Because the phase response curve is a fundamental input-output characteristic of oscillators, we developed a sensitivity analysis for oscillator models in the space of phase response curves. The proposed tool can be applied to high-dimensional oscillator models without facing the curse of dimensionality obstacle associated with numerical exploration of the parameter space. Application of this tool to a state-of-the-art model of circadian rhythms suggests that it can be useful and instrumental to biological investigations.

Item Type: Book Section
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:42
Last Modified: 03 Aug 2017 03:13
DOI: 10.1007/978-94-017-9047-5_3