CUED Publications database

Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints.

Liégeois, R and Ziegler, E and Phillips, C and Geurts, P and Gómez, F and Bahri, MA and Yeo, BTT and Soddu, A and Vanhaudenhuyse, A and Laureys, S and Sepulchre, R (2015) Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints. Brain Struct Funct, 221. pp. 2985-2997.

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Abstract

This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis based on the correlation between SC and FC averaged over the entire fMRI time series, we propose a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC. Assessing the statistical significance of the time series against random phase permutations, our data show a pronounced peak of significance for time window widths around 20-30 TR (40-60 s). Using the appropriate window width, we show that FC patterns oscillate between phases of high modularity, primarily shaped by anatomy, and phases of low modularity, primarily shaped by inter-network connectivity. Building upon recent results in dynamic FC, this emphasizes the potential role of SC as a transitory architecture between different highly connected resting-state FC patterns. Finally, we show that the regions contributing the most to these whole-brain level fluctuations of FC on the supporting anatomical architecture belong to the default mode and the executive control networks suggesting that they could be capturing consciousness-related processes such as mind wandering.

Item Type: Article
Uncontrolled Keywords: DWI Dynamics FMRI Functional connectivity Mind wandering Multimodal imaging Spontaneous activity Structural connectivity Windowing
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:59
Last Modified: 21 Sep 2017 01:40
DOI: