CUED Publications database

Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints

Liégeois, R and Ziegler, E and Phillips, C and Geurts, P and Gómez, F and Bahri, MA and Yeo, BTT and Soddu, A and Vanhaudenhuyse, A and Laureys, S and Sepulchre, R (2016) Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints. Brain Structure and Function, 221. pp. 2985-2997. ISSN 1863-2653

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This paper studies the link between resting-state functional connectivity (FC), measured by the correlations of fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis based on the correlation between SC and FC averaged over the entire fMRI time series, we propose a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC. Assessing the statistical significance of the time series against random phase permutations, our data show a pronounced peak of significance for time window widths around 20–30 TR (40–60 s). Using the appropriate window width, we show that FC patterns oscillate between phases of high modularity, primarily shaped by anatomy, and phases of low modularity, primarily shaped by inter-network connectivity. Building upon recent results in dynamic FC, this emphasizes the potential role of SC as a transitory architecture between different highly connected resting-state FC patterns. Finally, we show that the regions contributing the most to these whole-brain level fluctuations of FC on the supporting anatomical architecture belong to the default mode and the executive control networks suggesting that they could be capturing consciousness-related processes such as mind wandering.

Item Type: Article
Uncontrolled Keywords: DWI Dynamics FMRI Functional connectivity Mind wandering Multimodal imaging Spontaneous activity Structural connectivity Windowing Adult Brain Mapping Cerebral Cortex Cortical Synchronization Data Interpretation, Statistical Diffusion Magnetic Resonance Imaging Female Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:59
Last Modified: 09 Sep 2021 00:38
DOI: 10.1007/s00429-015-1083-y