CUED Publications database

Dynamic input conductances shape neuronal spiking

Drion, G and Franci, A and Dethier, J and Sepulchre, R (2015) Dynamic input conductances shape neuronal spiking. eNeuro, 2. ISSN 2373-2822

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Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current−voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis.

Item Type: Article
Uncontrolled Keywords: compensation firing pattern ion channels neuromodulation
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:45
Last Modified: 02 Sep 2021 04:16
DOI: 10.1523/ENEURO.0031-14.2015