CUED Publications database

Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography.

Turmezei, TD and Treece, GM and Gee, AH and Fotiadou, AF and Poole, KES (2015) Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography. Eur Radiol, 26. pp. 2047-2054.

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OBJECTIVE: To assess the relationship between proximal femoral cortical bone thickness and radiological hip osteoarthritis using quantitative 3D analysis of clinical computed tomography (CT) data. METHODS: Image analysis was performed on clinical CT imaging data from 203 female volunteers with a technique called cortical bone mapping (CBM). Colour thickness maps were created for each proximal femur. Statistical parametric mapping was performed to identify statistically significant differences in cortical bone thickness that corresponded with the severity of radiological hip osteoarthritis. Kellgren and Lawrence (K&L) grade, minimum joint space width (JSW) and a novel CT-based osteophyte score were also blindly assessed from the CT data. RESULTS: For each increase in K&L grade, cortical thickness increased by up to 25 % in distinct areas of the superolateral femoral head-neck junction and superior subchondral bone plate. For increasing severity of CT osteophytes, the increase in cortical thickness was more circumferential, involving a wider portion of the head-neck junction, with up to a 7 % increase in cortical thickness per increment in score. Results were not significant for minimum JSW. CONCLUSIONS: These findings indicate that quantitative 3D analysis of the proximal femur can identify changes in cortical bone thickness relevant to structural hip osteoarthritis. KEY POINTS: • CT is being increasingly used to assess bony involvement in osteoarthritis • CBM provides accurate and reliable quantitative analysis of cortical bone thickness • Cortical bone is thicker at the superior femoral head-neck with worse osteoarthritis • Regions of increased thickness co-locate with impingement and osteophyte formation • Quantitative 3D bone analysis could enable clinical disease prediction and therapy development.

Item Type: Article
Uncontrolled Keywords: Bone Helical CT Hip joint Imaging, three-dimensional Osteoarthritis Aged Aged, 80 and over Female Femur Head Femur Neck Humans Imaging, Three-Dimensional Middle Aged Osteoarthritis, Hip Osteophyte Risk Factors Severity of Illness Index Tomography, X-Ray Computed
Divisions: Div F > Machine Intelligence
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:08
Last Modified: 24 May 2018 02:08