CUED Publications database

Pressure-driven occlusive flow of a confined red blood cell.

Savin, T and Bandi, MM and Mahadevan, L (2016) Pressure-driven occlusive flow of a confined red blood cell. Soft Matter, 12. pp. 562-573.

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When red blood cells (RBCs) move through narrow capillaries in the microcirculation, they deform as they flow. In pathophysiological processes such as sickle cell disease and malaria, RBC motion and flow are severely restricted. To understand this threshold of occlusion, we use a combination of experiment and theory to study the motion of a single swollen RBC through a narrow glass capillary of varying inner diameter. By tracking the movement of the squeezed cell as it is driven by a controlled pressure drop, we measure the RBC velocity as a function of the pressure gradient as well as the local capillary diameter, and find that the effective blood viscosity in this regime increases with both decreasing RBC velocity and tube radius by following a power-law that depends upon the length of the confined cell. Our observations are consistent with a simple elasto-hydrodynamic model and highlight the role of lateral confinement in the occluded pressure-driven slow flow of soft confined objects.

Item Type: Article
Uncontrolled Keywords: Cell Adhesion Erythrocytes Hemorheology Hydrodynamics Models, Biological Pressure
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:59
Last Modified: 19 Jul 2018 07:02