CUED Publications database

Graphene-Based Interfaces Do Not Alter Target Nerve Cells.

Fabbro, A and Scaini, D and León, V and Vázquez, E and Cellot, G and Privitera, G and Lombardi, L and Torrisi, F and Tomarchio, F and Bonaccorso, F and Bosi, S and Ferrari, AC and Ballerini, L and Prato, M (2016) Graphene-Based Interfaces Do Not Alter Target Nerve Cells. ACS Nano, 10. pp. 615-623.

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Abstract

Neural-interfaces rely on the ability of electrodes to transduce stimuli into electrical patterns delivered to the brain. In addition to sensitivity to the stimuli, stability in the operating conditions and efficient charge transfer to neurons, the electrodes should not alter the physiological properties of the target tissue. Graphene is emerging as a promising material for neuro-interfacing applications, given its outstanding physico-chemical properties. Here, we use graphene-based substrates (GBSs) to interface neuronal growth. We test our GBSs on brain cell cultures by measuring functional and synaptic integrity of the emerging neuronal networks. We show that GBSs are permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.

Item Type: Article
Uncontrolled Keywords: graphene hippocampal cultures liquid phase exfoliation neuronal interfaces patch clamp synaptic networks Animals Animals, Newborn Biocompatible Materials Cell Adhesion Cell Survival Electrodes Graphite Hippocampus Microscopy, Atomic Force Nanotubes, Carbon Neurons Patch-Clamp Techniques Primary Cell Culture Rats Synapses Synaptic Transmission
Subjects: UNSPECIFIED
Divisions: Div B > Solid State Electronics and Nanoscale Science
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 18:58
Last Modified: 23 Nov 2017 03:34
DOI: