CUED Publications database

Cell Locomotion in One Dimension

Recho, P and Truskinovsky, L (2015) Cell Locomotion in One Dimension. In: Physical Models of Cell Motility. Springer.

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We overview a sub-class of mathematical models of lamellipodial cell motility on a substrate (crawling) that are based on a projection of a complex intra-cellular dynamics into one dimension. Despite the unavoidable oversimplifications associated with such a representation (loss of flow continuity, neglect of orientational order, misrepresentation of volume control mechanisms, etc.), one-dimensional models are extremely helpful in elucidating the individual roles of the three main active elements of lamellipodial motility: contraction, protrusion and adhesion. Moreover, by shifting the focus from shape to velocity, one-dimensional models reveal in an analytically transparent setting an intricate interplay between these mechanisms involving cooperation and competition.

Item Type: Book Section
Uncontrolled Keywords: Science
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 20:11
Last Modified: 22 May 2018 08:08