CUED Publications database

Ion channel degeneracy enables robust and tunable neuronal Firing rates

Drion, G and O'Leary, T and Marder, E (2015) Ion channel degeneracy enables robust and tunable neuronal Firing rates. Proceedings of the National Academy of Sciences of the United States of America, 112. E5361-E5370. ISSN 0027-8424

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Abstract

Firing rate is an important means of encoding information in the nervous system. To reliably encode a wide range of signals, neurons need to achieve a broad range of firing frequencies and to move smoothly between low and high firing rates. This can be achieved with specific ionic currents, such as A-type potassium currents, which can linearize the frequency-input current curve. By applying recently developed mathematical tools to a number of biophysical neuron models, we show how currents that are classically thought to permit low firing rates can paradoxically cause a jump to a high minimum firing rate when expressed at higher levels. Consequently, achieving and maintaining a low firing rate is surprisingly difficult and fragile in a biological context. This difficulty can be overcome via interactions between multiple currents, implying a need for ion channel degeneracy in the tuning of neuronal properties.

Item Type: Article
Uncontrolled Keywords: FI curve Type I excitability Type II excitability bifurcation reduced neuron model Action Potentials Animals Humans Ion Channels Ions Membrane Potentials Models, Neurological Neurons Potassium Potassium Channels
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 20:03
Last Modified: 26 Nov 2019 03:05
DOI: 10.1073/pnas.1516400112