CUED Publications database

Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation.

Marder, E and O'Leary, T and Shruti, S (2014) Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation. Annu Rev Neurosci, 37. pp. 329-346.

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Abstract

Neuromodulation underlies many behavioral states and has been extensively studied in small circuits. This has allowed the systematic exploration of how neuromodulatory substances and the neurons that release them can influence circuit function. The physiological state of a network and its level of activity can have profound effects on how the modulators act, a phenomenon known as state dependence. We provide insights from experiments and computational work that show how state dependence can arise and the consequences it can have for cellular and circuit function. These observations pose a general unsolved question that is relevant to all nervous systems: How is robust modulation achieved in spite of animal-to-animal variability and degenerate, nonlinear mechanisms for the production of neuronal and network activity?

Item Type: Article
Uncontrolled Keywords: biogenic amines central pattern generators intrinsic excitability neuropeptides stomatogastric nervous system synaptic strength Animals Behavior, Animal Connectome Homeostasis Models, Neurological Neural Pathways Neurons Neurotransmitter Agents Synapses
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:54
Last Modified: 21 Sep 2017 01:40
DOI: