CUED Publications database

Biodegradable Peptide-Silica Nanodonuts.

Maggini, L and Travaglini, L and Cabrera, I and Castro-Hartmann, P and De Cola, L (2016) Biodegradable Peptide-Silica Nanodonuts. Chemistry, 22. pp. 3697-3703.

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Abstract

We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated.

Item Type: Article
Uncontrolled Keywords: biodegradability breakable particles drug delivery hybrid organosilica particles materials science Aminopeptidases Doxorubicin Drug Delivery Systems HeLa Cells Humans Nanoparticles Peptides Silicon Dioxide
Subjects: UNSPECIFIED
Divisions: Div E > Manufacturing Systems
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:28
Last Modified: 23 Nov 2017 03:31
DOI: