CUED Publications database

Breakable mesoporous silica nanoparticles for targeted drug delivery.

Maggini, L and Cabrera, I and Ruiz-Carretero, A and Prasetyanto, EA and Robinet, E and De Cola, L (2016) Breakable mesoporous silica nanoparticles for targeted drug delivery. Nanoscale, 8. pp. 7240-7247.

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Abstract

"Pop goes the particle". Here we report on the preparation of redox responsive mesoporous organo-silica nanoparticles containing disulfide (S-S) bridges (ss-NPs) that, even upon the exohedral grafting of targeting ligands, retained their ability to undergo structural degradation, and increase their local release activity when exposed to a reducing agent. This degradation could be observed also inside glioma C6 cancer cells. Moreover, when anticancer drug-loaded pristine and derivatized ss-NPs were fed to glioma C6 cells, the responsive hybrids were more effective in their cytotoxic action compared to non-breakable particles. The possibility of tailoring the surface functionalization of this hybrid, yet preserving its self-destructive behavior and enhanced drug delivery properties, paves the way for the development of effective biodegradable materials for in vivo targeted drug delivery.

Item Type: Article
Uncontrolled Keywords: Antineoplastic Agents Cell Line, Tumor Dacarbazine Disulfides Drug Carriers Drug Delivery Systems Glioma Humans Nanoparticles Oxidation-Reduction Particle Size Porosity Reducing Agents Silicon Dioxide
Subjects: UNSPECIFIED
Divisions: Div E > Manufacturing Systems
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:00
Last Modified: 17 Nov 2017 20:20
DOI: