CUED Publications database

Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans

Takeishi, A and Yu, YV and Hapiak, VM and Bell, HW and O'Leary, T and Sengupta, P (2016) Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans. Neuron, 90. pp. 235-244. ISSN 0896-6273

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Thermosensation is critical for optimal regulation of physiology and behavior. C. elegans acclimates to its cultivation temperature (Tc) and exhibits thermosensitive behaviors at temperatures relative to Tc. These behaviors are mediated primarily by the AFD sensory neurons, which are extraordinarily thermosensitive and respond to thermal fluctuations at temperatures above a Tc-determined threshold. Although cGMP signaling is necessary for thermotransduction, the thermosensors in AFD are unknown. We show that AFD-specific receptor guanylyl cyclases (rGCs) are instructive for thermosensation. In addition to being necessary for thermotransduction, ectopic expression of these rGCs confers highly temperature-dependent responses onto diverse cell types. We find that the temperature response threshold is determined by the rGC and cellular context, and that multiple domains contribute to their thermosensory properties. Identification of thermosensory rGCs in C. elegans provides insight into mechanisms of thermosensation and thermal acclimation and suggests that rGCs may represent a new family of molecular thermosensors.

Item Type: Article
Uncontrolled Keywords: Animals Animals, Genetically Modified Caenorhabditis elegans Muscle Cells Mutation Receptors, Guanylate Cyclase-Coupled Sensory Receptor Cells Temperature Thermosensing
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:35
Last Modified: 09 Sep 2021 00:40
DOI: 10.1016/j.neuron.2016.03.002