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Mitochondrion- and endoplasmic reticulum-induced sk channel dysregulation as a potential origin of the selective neurodegeneration in parkinson’s disease

Drion, G and Seutin, V and Sepulchre, R (2012) Mitochondrion- and endoplasmic reticulum-induced sk channel dysregulation as a potential origin of the selective neurodegeneration in parkinson’s disease. In: Systems Biology of Parkinson's Disease. UNSPECIFIED, pp. 57-79.

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Abstract

Mitochondrial dysfunction and metabolic issues are known to have strong implications in the pathogenesis of Parkinson’s disease (PD). But it is also known that the neuronal loss leading to PD symptoms is selective for particular areas of the brain (see Chap. 1). In particular, the characteristic motor symptoms of PD are mainly due to abnormal neuronal activity in the basal ganglia, through the degeneration of substantia nigra pars compacta (SNc), but not ventral tegmental area (VTA), dopaminergic (DA) neurons. How a metabolic dysfunction triggers such a selective loss is considered from a range of perspectives in several contributions to this volume. The aim of this chapter is to investigate the potential role of small conductance calcium-activated potassium (SK) channels in this selective degeneration.Based on a recently proposed model and experimental data, we underline the fundamental role of SK channels in regulating the excitability of SNc DA neurons. The fact that SK channels do not play this regulating role in VTA DA neurons

Item Type: Book Section
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:34
Last Modified: 26 Oct 2017 01:46
DOI: 10.1007/978-1-4614-3411-5_4