The dynamic mechanical properties of cellularised aggregates

Khalilgharibi, N and Fouchard, J and Recho, P and Charras, G and Kabla, A (2016) The dynamic mechanical properties of cellularised aggregates. Current Opinion in Cell Biology, 42. pp. 113-120. ISSN 0955-0674

Abstract

Cellularised materials are composed of cells interfaced through specialised intercellular junctions that link the cytoskeleton of one cell to that of its neighbours allowing for transmission of forces. Cellularised materials are common in early development and adult tissues where they can be found in the form of cell sheets, cysts, or amorphous aggregates and in pathophysiological conditions such as cancerous tumours. Given the growing realisation that forces can regulate cell physiology and developmental processes, understanding how cellularised materials deform under mechanical stress or dissipate stress appear as key biological questions. In this review, we will discuss the dynamic mechanical properties of cellularised materials devoid of extracellular matrix.