CUED Publications database

Alginate nanoparticles protect ferrous from oxidation: Potential iron delivery system

Katuwavila, NP and Perera, ADLC and Dahanayake, D and Karunaratne, V and Amaratunga, GAJ and Karunaratne, DN (2016) Alginate nanoparticles protect ferrous from oxidation: Potential iron delivery system. International Journal of Pharmaceutics, 513. pp. 404-409.

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A novel, efficient delivery system for iron (Fe²⁺) was developed using the alginate biopolymer. Iron loaded alginate nanoparticles were synthesized by a controlled ionic gelation method and was characterized with respect to particle size, zeta potential, morphology and encapsulation efficiency. Successful loading was confirmed with Fourier Transform Infrared spectroscopy and Thermogravimetric Analysis. Electron energy loss spectroscopy study corroborated the loading of ferrous into the alginate nanoparticles. Iron encapsulation (70%) was optimized at 0.06% Fe (w/v) leading to the formation of iron loaded alginate nanoparticles with a size range of 15-30nm and with a negative zeta potential (-38mV). The in vitro release studies showed a prolonged release profile for 96h. Release of iron was around 65-70% at pH of 6 and 7.4 whereas it was less than 20% at pH 2.The initial burst release upto 8h followed zero order kinetics at all three pH values. All the release profiles beyond 8h best fitted the Korsmeyer-Peppas model of diffusion. Non Fickian diffusion was observed at pH 6 and 7.4 while at pH 2 Fickian diffusion was observed.

Item Type: Article
Uncontrolled Keywords: alginate nanoparticles anemia bioavailability ferrous sulfate iron loaded nanocomposite
Divisions: Div B > Electronics, Power & Energy Conversion
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:32
Last Modified: 15 Apr 2021 05:47
DOI: 10.1016/j.ijpharm.2016.09.053