CUED Publications database

Induced sensorimotor brain plasticity controls pain in phantom limb patients

Yanagisawa, T and Fukuma, R and Seymour, B and Hosomi, K and Kishima, H and Shimizu, T and Yokoi, H and Hirata, M and Yoshimine, T and Kamitani, Y and Saitoh, Y (2016) Induced sensorimotor brain plasticity controls pain in phantom limb patients. Nature Communications, 7.

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Abstract

The cause of pain in a phantom limb after partial or complete deafferentation is an important problem. A popular but increasingly controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, suggesting that experimental induction of further reorganization should affect the pain, especially if it results in functional restoration. Here we use a brain-machine interface (BMI) based on real-time magnetoencephalography signals to reconstruct affected hand movements with a robotic hand. BMI training induces significant plasticity in the sensorimotor cortex, manifested as improved discriminability of movement information and enhanced prosthetic control. Contrary to our expectation that functional restoration would reduce pain, the BMI training with the phantom hand intensifies the pain. In contrast, BMI training designed to dissociate the prosthetic and phantom hands actually reduces pain. These results reveal a functional relevance between sensorimotor cortical plasticity and pain, and may provide a novel treatment with BMI neurofeedback.

Item Type: Article
Uncontrolled Keywords: neural decoding neuropathic pain preclinical research
Subjects: UNSPECIFIED
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:56
Last Modified: 21 Sep 2017 01:36
DOI: