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Dopamine alters the fidelity of working memory representations according to attentional demands

Fallon, SJ and Zokaei, N and Norbury, A and Manohar, SG and Husain, M (2017) Dopamine alters the fidelity of working memory representations according to attentional demands. Journal of Cognitive Neuroscience, 29. pp. 728-738. ISSN 0898-929X

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Capacity limitations in working memory (WM) necessitate the need to effectively control its contents. Here, we examined the effect of cabergoline, a dopamine D receptor agonist, on WM using a continuous report paradigm that allowed us to assess the fidelity with which items are stored. We assessed recall performance under three different gating conditions: remembering only one item, being cued to remember one target among distractors, and having to remember all items. Cabergoline had differential effects on recall performance according to whether distractors had to be ignored and whether mnemonic resources could be deployed exclusively to the target. Compared with placebo, cabergoline improved mnemonic performance when there were no distractors but significantly reduced performance when distractors were presented in a precue condition. No significant difference in performance was observed under cabergoline when all items hadtoberemembered.Byapplyingastochasticmodelofresponse selection, we established that the causes of drug-induced changes in performance were due to changes in the precision with which items were stored in WM. However, there was no change in the extent to which distractors were mistaken for targets. Thus, D agonism causes changes in the fidelity of mnemonic representations without altering interference between memoranda. 2 2

Item Type: Article
Uncontrolled Keywords: Adult Attention Cabergoline Dopamine Dopamine Agonists Ergolines Female Humans Male Memory, Short-Term Mental Recall Receptors, Dopamine D2 Task Performance and Analysis Visual Perception Young Adult
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:11
Last Modified: 08 Apr 2021 07:13
DOI: 10.1162/jocn_a_01073