CUED Publications database

Strong and tough nanofibrous hydrogel composites based on biomimetic principles

Tonsomboon, K and Butcher, AL and Oyen, ML (2016) Strong and tough nanofibrous hydrogel composites based on biomimetic principles. Materials Science and Engineering: C, 72. pp. 220-227.

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Abstract

Mechanically robust hydrogels are required for many tissue engineering applications to serve as cell-supporting structures. Unlike natural tissues, the majority of existing tough hydrogels lack ordered microstructures organized to withstand specific loading conditions. In this work, electrospun gelatin nanofibres, mimicking the collagen network in native tissues, are used to strengthen and resist crack propagation in brittle alginate hydrogels. Aligned nanofibre reinforcement enhances the tensile strength of the hydrogels by up to two orders of magnitude. The nanofibres can be arranged as multilayer laminates with varying orientations, which increases the toughness by two orders of magnitude compared with the unreinforced hydrogel. This work demonstrates a two-part strategy of fibre reinforcement and composite lamination in manufacturing strong and tough hydrogels with flexible microstructures to suit different mechanical and biomedical requirements.

Item Type: Article
Uncontrolled Keywords: fracture hydrogel nanocomposite nanofibres toughness
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:30
Last Modified: 24 Aug 2017 01:30
DOI: