CUED Publications database

Sub-nanoscale free volume and local elastic modulus of chitosan-carbon nanotube biomimetic nanocomposite scaffold-materials

Axpe, E and Bugnicourt, L and Merida, D and Goiriena-Goikoetxea, M and Unzueta, I and Sanchez-Eugenia, R and Garcia, JA and Plazaola, F and Contera, S (2015) Sub-nanoscale free volume and local elastic modulus of chitosan-carbon nanotube biomimetic nanocomposite scaffold-materials. Journal of Materials Chemistry B, 3. pp. 3169-3176. ISSN 2050-7518

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Abstract

© The Royal Society of Chemistry 2015. Future progress in materials for tissue engineering and 3D cell cultures applications requires control of two key physical properties: nanoscale mechanical properties and mass transport. These requirements remain uncontrolled partly due to a lack of physical parameters and quantitative measurements. Using chitosan scaffolds as a model system in close-to-physiological conditions and a combination of experimental techniques and theory, we link structure with local nanomechanical properties. Additionally we introduce a parameter, the free volume, to predict variations in transport properties. By fabricating nanocomposites with single walled carbon nanotubes (SWNTs) we are able to test our approach: incorporation of acid-treated, soluble, ∼80 nm SWNTs in a chitosan matrix leads to a 2 fold increase in mean local elastic modulus and a decrease of 3% of the free volume available for oxygen diffusion. Inclusion of hydrophobic, ∼800 nm SWNTs leads to a 100 fold increase of elastic modulus and doubles the voids percentage available for the transport of glucose.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:16
Last Modified: 10 Aug 2017 01:37
DOI: