CUED Publications database

Critical transitions in chronic disease: transferring concepts from ecology to systems medicine.

Trefois, C and Antony, PMA and Goncalves, J and Skupin, A and Balling, R (2014) Critical transitions in chronic disease: transferring concepts from ecology to systems medicine. Curr Opin Biotechnol, 34. pp. 48-55. ISSN 0958-1669

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Abstract

Ecosystems and biological systems are known to be inherently complex and to exhibit nonlinear dynamics. Diseases such as microbiome dysregulation or depression can be seen as complex systems as well and were shown to exhibit patterns of nonlinearity in their response to perturbations. These nonlinearities can be revealed by a sudden shift in system states, for instance from health to disease. The identification and characterization of early warning signals which could predict upcoming critical transitions is of primordial interest as prevention of disease onset is a major aim in health care. In this review, we focus on recent evidence for critical transitions in diseases and discuss the potential of such studies for therapeutic applications.

Item Type: Article
Uncontrolled Keywords: Animals Chronic Disease Cross-Sectional Studies Ecosystem Humans Longitudinal Studies
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 20:00
Last Modified: 07 Sep 2017 01:43
DOI: