CUED Publications database

Fine-grained nociceptive maps in primary somatosensory cortex.

Mancini, F and Haggard, P and Iannetti, GD and Longo, MR and Sereno, MI (2012) Fine-grained nociceptive maps in primary somatosensory cortex. J Neurosci, 32. pp. 17155-17162.

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Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be. Given that nociceptive innervation density is relatively low on distal skin regions such as the digits, one might conclude that the nociceptive system lacks fine representation of these regions. Indeed, only gross spatial organization of nociceptive maps has been reported so far. However, here we reveal the existence of fine-grained somatotopy for nociceptive inputs to the digits in human primary somatosensory cortex (SI). Using painful nociceptive-selective laser stimuli to the hand, and phase-encoded functional magnetic resonance imaging analysis methods, we observed somatotopic maps of the digits in contralateral SI. These nociceptive maps were highly aligned with maps of non-painful tactile stimuli, suggesting comparable cortical representations for, and possible interactions between, mechanoreceptive and nociceptive signals. Our findings may also be valuable for future studies tracking the time course and the spatial pattern of plastic changes in cortical organization involved in chronic pain.

Item Type: Article
Uncontrolled Keywords: Brain Mapping Female Hand Humans Magnetic Resonance Imaging Male Nociception Pain Physical Stimulation Skin Somatosensory Cortex
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:13
Last Modified: 22 Jun 2018 20:27