CUED Publications database

Inhibitory Plasticity: Balance, Control, and Codependence

Hennequin, GJE and Agnes, EJ and Vogels, TPV (2017) Inhibitory Plasticity: Balance, Control, and Codependence. Annual Review of Neuroscience, 40. pp. 557-579.

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Inhibitory neurons, although relatively few in number, exert powerful control over brain circuits. They stabilize network activity in the face of strong feedback excitation and actively engage in computations. Recent studies reveal the importance of a precise balance of excitation and inhibition in neural circuits, which often requires exquisite fine-tuning of inhibitory connections. We review inhibitory synaptic plasticity and its roles in shaping both feedforward and feedback control. We discuss the necessity of complex, codependent plasticity mechanisms to build nontrivial, functioning networks, and we end by summarizing experimental evidence of such interactions.

Item Type: Article
Uncontrolled Keywords: inhibition GABA synaptic plasticity network dynamics feedback control modeling
Divisions: Div F > Computational and Biological Learning
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:58
Last Modified: 18 Feb 2021 18:19
DOI: 10.1146/annurev-neuro-072116-031005