CUED Publications database

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.

Knowles, TPJ and Oppenheim, TW and Buell, AK and Chirgadze, DY and Welland, ME (2010) Nanostructured films from hierarchical self-assembly of amyloidogenic proteins. Nat Nanotechnol, 5. pp. 204-207. ISSN 1748-3387

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Abstract

In nature, sophisticated functional materials are created through hierarchical self-assembly of simple nanoscale motifs. In the laboratory, much progress has been made in the controlled assembly of molecules into one-, two- and three-dimensional artificial nanostructures, but bridging from the nanoscale to the macroscale to create useful macroscopic materials remains a challenge. Here we show a scalable self-assembly approach to making free-standing films from amyloid protein fibrils. The films were well ordered and highly rigid, with a Young's modulus of up to 5-7 GPa, which is comparable to the highest values for proteinaceous materials found in nature. We show that the self-organizing protein scaffolds can align otherwise unstructured components (such as fluorophores) within the macroscopic films. Multiscale self-assembly that relies on highly specific biomolecular interactions is an attractive path for realizing new multifunctional materials built from the bottom up.

Item Type: Article
Uncontrolled Keywords: Amyloid Elastic Modulus Fluorescent Dyes Nanostructures Nanotechnology Protein Multimerization Proteins X-Ray Diffraction
Subjects: UNSPECIFIED
Divisions: Div B > Solid State Electronics and Nanoscale Science
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:07
Last Modified: 10 Apr 2021 01:41
DOI: 10.1038/nnano.2010.26