CUED Publications database

A Microfluidic Ion Pump for In Vivo Drug Delivery.

Uguz, I and Proctor, CM and Curto, VF and Pappa, A-M and Donahue, MJ and Ferro, M and Owens, RM and Khodagholy, D and Inal, S and Malliaras, GG (2017) A Microfluidic Ion Pump for In Vivo Drug Delivery. Adv Mater, 29. ISSN 0935-9648

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Abstract

Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

Item Type: Article
Uncontrolled Keywords: PEDOT:PSS organic bioelectronics organic electronic ion pumps Animals Drug Delivery Systems Electrophoresis Ion Pumps Microfluidics gamma-Aminobutyric Acid
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 10 Sep 2017 20:10
Last Modified: 12 Apr 2021 20:32
DOI: 10.1002/adma.201701217