CUED Publications database

PEDOT:PSS microelectrode arrays for hippocampal cell culture electrophysiological recordings

Koutsouras, DA and Hama, A and Pas, J and Gkoupidenis, P and Hivert, B and Faivre-Sarrailh, C and Di Pasquale, E and Owens, RM and Malliaras, GG (2017) PEDOT:PSS microelectrode arrays for hippocampal cell culture electrophysiological recordings. MRS Communications, 7. pp. 259-265. ISSN 2159-6859

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Abstract

© 2017 Materials Research Society. In vitro electrophysiology using microelectrode arrays (MEAs) plays an important role in understanding fundamental biologic processes, screening potential drugs and assessing the toxicity of chemicals. Low electrode impedance and ability to sustain viable cultures are the key technology requirements. We show that MEAs consisting of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and coated with poly-L-lysine satisfy these requirements. Hippocampal cell cultures, maintained for 3-6 weeks on these MEAs, give high quality recordings of neural activity. This enables the observation of drug-induced activity changes, which paves the way for using these devices in in vitro drug screening and toxicology applications.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 10 Sep 2017 20:11
Last Modified: 13 Apr 2021 07:41
DOI: 10.1557/mrc.2017.34