CUED Publications database

Organic Transistor Arrays Integrated with Finger-Powered Microfluidics for Multianalyte Saliva Testing.

Pappa, A-M and Curto, VF and Braendlein, M and Strakosas, X and Donahue, MJ and Fiocchi, M and Malliaras, GG and Owens, RM (2016) Organic Transistor Arrays Integrated with Finger-Powered Microfluidics for Multianalyte Saliva Testing. Adv Healthc Mater, 5. pp. 2295-2302.

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Abstract

A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless "finger-powered" microfluidic, for quantitative screening of glucose, lactate, and cholesterol levels. A biofunctionalization method is designed, which provides selectivity towards specific metabolites as well as minimization of any background interference. In addition, a simple method is developed to facilitate multi-analyte sensing and avoid electrical crosstalk between the different transistors by electrically isolating the individual devices. The resulting biosensing platform, verified using human samples, offers the possibility to be used in easy-to-obtain biofluids with low abundance metabolites, such as saliva. Based on our proposed method, other types of enzymatic biosensors can be integrated into the array to achieve multiplexed, noninvasive, personalized point-of-care diagnostics.

Item Type: Article
Uncontrolled Keywords: microfluidics multianalyte organic electrochemical transistors point-of-care diagnostics saliva
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 10 Sep 2017 20:11
Last Modified: 05 Oct 2017 02:07
DOI: