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Integrated reactive ion etching to pattern cross-linked hydrophilic polymer structures for protein immobilization

Bhatnagar, P and Strickland, AD and Kim, I and Malliaras, GG and Batt, CA (2007) Integrated reactive ion etching to pattern cross-linked hydrophilic polymer structures for protein immobilization. Applied Physics Letters, 90. ISSN 0003-6951

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Abstract

Patterning of cross-linked hydrophilic polymer features using reactive ion etching (RIE) capable of covalently immobilizing proteins has been achieved. Projection photolithography was used to pattern photoresist to create micromolds. Vapor phase molecular self-assembly of polymerizable monolayer in molds allowed covalent binding of hydrogel on surface during free-radical polymerization. Excess hydrogel blanket film was consumed with oxygen RIE resulting into hydrogel pattern of 1 μm size aligned to prefabricated silicon oxide structures. Proteins were finally coupled through their primary amine groups selectively to acid functionalized hydrogel features through stable amide linkages using 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N -hydroxysulfosuccinimide. © 2007 American Institute of Physics.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 10 Sep 2017 20:11
Last Modified: 23 Nov 2017 03:49
DOI: