Hallou, A and Jennings, J and Kabla, AJ (2017) Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination. Royal Society Open Science, 4. 161007-. ISSN 2054-5703
Full text not available from this repository.Abstract
Heterogeneity within tumour cell populations is commonly observed in most cancers. However, its impact on metastatic dissemination, one of the primary determinants of the disease prognosis, remains poorly understood. Working with a simplified numerical model of tumour spheroids, we investigated the impact of mechanical heterogeneity on the onset of tumour invasion into surrounding tissues. Our work establishes a positive link between tumour heterogeneity and metastatic dissemination, and recapitulates a number of invasion patterns identified in vivo, such as multicellular finger-like protrusions. Two complementary mechanisms are at play in heterogeneous tumours. A small proportion of stronger cells are able to initiate and lead the escape of cells, while collective effects in the bulk of the tumour provide the coordination required to sustain the invasive process through multicellular streaming. This suggests that the multicellular dynamics observed during metastasis is a generic feature of mechanically heterogeneous cell populations and might rely on a limited and generic set of attributes.
Item Type: | Article |
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Uncontrolled Keywords: | cancer collective invasion metastasis tumour heterogeneity |
Subjects: | UNSPECIFIED |
Divisions: | Div C > Biomechanics Div C > Materials Engineering |
Depositing User: | Cron Job |
Date Deposited: | 08 Sep 2017 20:07 |
Last Modified: | 10 Apr 2021 00:47 |
DOI: | 10.1098/rsos.161007 |