CUED Publications database

In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR

Li, R and Rajan, R and Wong, WCV and Reid, DG and Duer, MJ and Somovilla, VJ and Martinez-Saez, N and Bernardes, GJL and Hayward, R and Shanahan, CM (2017) In situ characterization of advanced glycation end products (AGEs) in collagen and model extracellular matrix by solid state NMR. Chemical Communications, 53. pp. 13316-13319. ISSN 1359-7345

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Abstract

Non-enzymatic glycation of extracellular matrix with (U- C )-d-ribose-5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH -CH(OH)NHR) substructures. Changes in charged residue proportions and distribution may be as important as crosslinking in provoking and understanding harmful tissue changes. 13 5 3

Item Type: Article
Uncontrolled Keywords: Collagen Extracellular Matrix Glycation End Products, Advanced Models, Biological Nuclear Magnetic Resonance, Biomolecular
Subjects: UNSPECIFIED
Divisions: UNSPECIFIED
Depositing User: Cron Job
Date Deposited: 25 Jun 2019 02:48
Last Modified: 13 Apr 2021 09:25
DOI: 10.1039/c7cc06624d