CUED Publications database

Harnessing Surface-Functionalized Metal-Organic Frameworks for Selective Tumor Cell Capture

Wheatley, AEH and Qi, X and Chang, Z and Zhang, D and Binder, KJ and Shen, S and Huang, YYS and Bai, Y and Liu, H (2017) Harnessing Surface-Functionalized Metal-Organic Frameworks for Selective Tumor Cell Capture. Chemistry of Materials, 29. pp. 8052-8056. ISSN 0897-4756 (Unpublished)

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Abstract

A platform based on a metal-organic framework (MOF) bearing free carboxylic acid groups has been developed for tumor cell capture and potential drug screening applications. A zinc-based MOF expressing uncoordinated carboxylic acids (ZnMOF-COOH) was grown on a ZnO substrate. Post-synthetic modification (PSM) of the acid groups gave a composite material that expressed peptide linkages and allowed the immobilization of anti-epithelial cell adhesion molecule (anti-EpCAM) antibody. This strategy offers a universal method for the controllable immobilization of antibodies and even enzymes on the surface of a MOF. The resulting immunotrapper exhibited excellent capture ability, demonstrating high efficiency and selectivity towards EpCAM-positive tumor cells. The promotion of tumor cell adhesion is attributed to the 3-dimentional (3D) structure of the composite, which revealed spine-like microstructures.

Item Type: Article
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 21 Oct 2017 20:12
Last Modified: 15 Apr 2021 07:06
DOI: 10.1021/acs.chemmater.7b03269