CUED Publications database

Importance of vesicle release stochasticity in neuro-spike communication

Ramezani, H and Akan, OB (2017) Importance of vesicle release stochasticity in neuro-spike communication. In: 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017-7-11 to 2017-7-15, Jeju Island, Korea pp. 3343-3347.. (Unpublished)

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Abstract

Aim of this paper is proposing a stochastic model for vesicle release process, a part of neuro-spike communication. Hence, we study biological events occurring in this process and use microphysiological simulations to observe functionality of these events. Since the most important source of variability in vesicle release probability is opening of voltage dependent calcium channels (VDCCs) followed by influx of calcium ions through these channels, we propose a stochastic model for this event, while using a deterministic model for other variability sources. To capture the stochasticity of calcium influx to pre-synaptic neuron in our model, we study its statistics and find that it can be modeled by a distribution defined based on Normal and Logistic distributions.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Subjects: UNSPECIFIED
Divisions: Div B > Photonics
Depositing User: Unnamed user with email sms67@cam.ac.uk
Date Deposited: 31 Oct 2017 01:32
Last Modified: 15 Apr 2021 02:17
DOI: 10.1109/EMBC.2017.8037572