CUED Publications database

Internalization of growth factor-receptor complexes under the influence of antibodies initiates cell apoptosis in vitro.

Lavrovsky, VA and Chagin, AS and Subkhankulova, TN (1999) Internalization of growth factor-receptor complexes under the influence of antibodies initiates cell apoptosis in vitro. Eur J Cell Biol, 78. pp. 194-198. ISSN 0171-9335

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Abstract

Antibodies against growth factors like IGF1, IGF2, aFGF, bFGF and, to a certain extent, TGF alpha and EGF were shown to cause apoptosis of normal and tumorigenic cells while apoptotic cell death could be prevented neither by single growth factors nor by serum. Antibodies to growth factors caused apoptosis by interacting with growth factors bound to their receptors on the cell surface. The phenomenon is likely to be associated with active internalization of growth factor receptors loaded with ligands. Apparently these activated receptors are essential for cell survival and their disappearance from the cell surface initiates apoptosis.

Item Type: Article
Uncontrolled Keywords: Animals Antibodies, Monoclonal Apoptosis Growth Substances Humans Mice Receptors, Growth Factor Tumor Cells, Cultured
Subjects: UNSPECIFIED
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 27 Oct 2017 20:10
Last Modified: 20 Jun 2019 03:25
DOI: 10.1016/S0171-9335(99)80098-3