CUED Publications database

Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility.

Yu, JY and Kay, K and Liu, DF and Grossrubatscher, I and Loback, A and Sosa, M and Chung, JE and Karlsson, MP and Larkin, MC and Frank, LM (2017) Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility. Elife, 6.

Full text not available from this repository.

Abstract

While ongoing experience proceeds continuously, memories of past experience are often recalled as episodes with defined beginnings and ends. The neural mechanisms that lead to the formation of discrete episodes from the stream of neural activity patterns representing ongoing experience are unknown. To investigate these mechanisms, we recorded neural activity in the rat hippocampus and prefrontal cortex, structures critical for memory processes. We show that during spatial navigation, hippocampal CA1 place cells maintain a continuous spatial representation across different states of motion (movement and immobility). In contrast, during sharp-wave ripples (SWRs), when representations of experience are transiently reactivated from memory, movement- and immobility-associated activity patterns are most often reactivated separately. Concurrently, distinct hippocampal reactivations of movement- or immobility-associated representations are accompanied by distinct modulation patterns in prefrontal cortex. These findings demonstrate a continuous representation of ongoing experience can be separated into independently reactivated memory representations.

Item Type: Article
Uncontrolled Keywords: hippocampus memory neuroscience prefrontal cortex rat sharp wave-ripple Animals Brain Waves CA1 Region, Hippocampal Interneurons Male Mental Recall Movement Prefrontal Cortex Pyramidal Cells Rats Rats, Long-Evans Rest Spatial Memory Temporal Lobe
Subjects: UNSPECIFIED
Divisions: Div F > Control
Depositing User: Cron Job
Date Deposited: 09 Mar 2018 20:14
Last Modified: 28 Nov 2019 02:56
DOI: 10.7554/eLife.27621