CUED Publications database

Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation.

Blanchard, GB and Kabla, AJ and Schultz, NL and Butler, LC and Sanson, B and Gorfinkiel, N and Mahadevan, L and Adams, RJ (2009) Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation. Nat Methods, 6. pp. 458-464.

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The dynamic reshaping of tissues during morphogenesis results from a combination of individual cell behaviors and collective cell rearrangements. However, a comprehensive framework to unambiguously measure and link cell behavior to tissue morphogenesis is lacking. Here we introduce such a kinematic framework, bridging cell and tissue behaviors at an intermediate, mesoscopic, level of cell clusters or domains. By measuring domain deformation in terms of the relative motion of cell positions and the evolution of their shapes, we characterized the basic invariant quantities that measure fundamental classes of cell behavior, namely tensorial rates of cell shape change and cell intercalation. In doing so we introduce an explicit definition of cell intercalation as a continuous process. We mapped strain rates spatiotemporally in three models of tissue morphogenesis, gaining insight into morphogenetic mechanisms. Our quantitative approach has broad relevance for the precise characterization and comparison of morphogenetic phenotypes.

Item Type: Article
Uncontrolled Keywords: Cell Physiological Phenomena Cell Size Computer Simulation Elastic Modulus Elasticity Imaging Techniques Mechanotransduction, Cellular Models, Biological Morphogenesis Stress, Mechanical
Divisions: Div C > Biomechanics
Depositing User: Cron Job
Date Deposited: 17 Jul 2017 19:17
Last Modified: 10 Apr 2021 22:44
DOI: 10.1038/nmeth.1327